This course provides a detailed overview of drug disposition in the body including absorption, distribution, and elimination process. Special attention is given to the understanding mathematical model to representing the drug process in the body and apply the pharmacokinetic equation to find the pharmacokinetic parameters such as elimination rate constant and half-life, t max, C max, volume of distribution, Clearance, and so on for each model of intravein, oral, infuse and multiple drug dosage regimen administration and nonlinear pharmacokinetics. Attention will also be given to the bioavailability and bioequivalence, Drug Distribution, Protein Binding, and Clearance, pharmacogenomics, effect of food and excipient on drug pharmacokinetic. The student will gain an understanding of application of pharmacokinetic in research and development of drug product and in clinical situation.
Introduction to Pharmacokinetics
One-Compartment Open Model: Intravenous Bolus Administration
Two-Compartment Open Model: Intravenous Bolus Administration